Table 3. On-aspirin platelet aggregation according to genotype in 985 patients with stable coronary artery disease.
| Platelet aggregation | P-values | ||||||||
| (multivariable-adjusted) | |||||||||
| Gene | Polymorphism | Genotype | MEA (AU × min) | MEA (AU × min) | VerifyNow Aspirin | MEA | MEA | VerifyNow | |
| (%) | AA 1.0 mmol/L | Collagen 1.0 µg/mL | (Aspirin Reaction units) | AA | Collagen | ||||
| ITGB3 | rs5918 | TT (68.5) | 145 (137–154) | 237 (226–249) | 433 (430–436) | ||||
| TC (28.5) | 147 (135–160) | 250 (232–270) | 434 (430–438) | 0.98 | 0.43 | 0.71 | |||
| CC (3.0) | 158 (127–197) | 244 (200–299) | 425 (410–439) | ||||||
| PTGS1 | rs10306114 | AA (87.0) | 147 (140–154) | 240 (229–250) | 433 (430–435) | ||||
| AG (12.5) | 140 (120–164) | 250 (223–282) | 437 (430–444) | 0.12 | 0.55 | 0.45 | |||
| GG (0.5) | 218 (−) | 249 (−) | 465 (−) | ||||||
| PTGS1 | rs1236913 | CC (86.0) | 145 (138–153) | 243 (233–254) | 433 (431–436) | ||||
| CT (13.0) | 150 (132–169) | 232 (208–259) | 432 (426–439) | 0.43 | 0.14 | 0.68 | |||
| TT (1.0) | 144 (94–220) | 190 (115–312) | 417 (404–431) | ||||||
| TBXA2R | rs4523 | GG (44.5) | 147 (137–158) | 238 (224–254) | 432 (428–435) | ||||
| GA (44.5) | 142 (133–152) | 238 (224–253) | 434 (431–438) | 0.78 | 0.71 | 0.82 | |||
| AA (11.0) | 160 (137–185) | 266 (236–301) | 434 (424–444) | ||||||
| TBXA2R | rs1131882 | GG (74.5) | 145 (137–154) | 238 (227–250) | 431 (429–434) | ||||
| GA (23.5) | 146 (132–160) | 244 (224–266) | 439 (433–445) | 0.83 | 0.86 | 0.65 | |||
| AA (2.0) | 208 (166–260) | 335 (249–451) | 430 (402–460) | ||||||
| P2RY1 | rs1065776 | CC (92.5) | 147 (140–154) | 241 (231–252) | 433 (431–436) | ||||
| CT (7.0) | 137 (112–167) | 242 (207–282) | 435 (427–443) | 0.68 | 0.93 | 0.87 | |||
| TT (0.5) | 133 (−) | 181 (−) | 402 (−) | ||||||
| P2RY1 | rs701265 | AA (75.0) | 146 (138–154) | 242 (231–254) | 433 (430–436) | ||||
| AG (23) | 146 (132–160) | 238 (219–259) | 433 (429–438) | 0.17 | 0.31 | 0.22 | |||
| GG (2) | 154 (118–201) | 239 (188–304) | 446 (429–465) | ||||||
| P2RY12 | rs6809699 | CC (72.0) | 143 (135–151) | 236 (225–248) | 432 (429–434) | ||||
| CA (26.5) | 154 (141–169) | 260 (240–281) | 437 (432–442) | 0.50 | 0.37 | 0.18 | |||
| AA (1.5) | 162 (123–214) | 195 (146–262) | 433 (419–447) | ||||||
| P2RY12 | rs10935838 | GG (71.5) | 142 (134–151) | 235 (224–247) | 431 (429–434) | ||||
| GA (27.0) | 155 (143–169) | 261 (242–281) | 438 (433–442) | 0.33 | 0.30 | 0.11 | |||
| AA (1.5) | 162 (123–214) | 195 (146–262) | 433 (419–447) | ||||||
| GP1BA | rs6065 | CC (87.5) | 147 (140–155) | 239 (229–250) | 433 (430–435) | ||||
| CT (12.0) | 144 (128–161) | 257 (231–285) | 435 (427–443) | 0.24 | 0.90 | 0.98 | |||
| TT (0.5) | 72 (27–192) | 207 (123–349) | 427 (407–449) | ||||||
| GP6 | rs1613662 | AA (69.5) | 148 (140–157) | 238 (226–250) | 433 (430–436) | ||||
| AG (27.5) | 143 (131–157) | 251 (232–271) | 433 (428–438) | 0.72 | 0.08 | 0.62 | |||
| GG (3.0) | 112 (76–166) | 236 (182–306) | 431 (418–444) | ||||||
| PLA2G7 | rs1051931 | GG (62.5) | 146 (138–155) | 244 (232–257) | 432 (429–435) | ||||
| GA (33.5) | 145 (133–157) | 232 (216–250) | 433 (429–438) | 0.73 | 0.10 | 0.13 | |||
| AA (4.0) | 154 (123–192) | 264 (221–315) | 441 (425–457) | ||||||
| F13A1 | rs5985 | CC (55.5) | 146 (137–155) | 234 (221–247) | 432 (429–435) | ||||
| CA (37.0) | 146 (135–157) | 253 (237–270) | 435 (431–439) | 0.72 | 0.19 | 0.66 | |||
| AA (7.5) | 150 (128–177) | 237 (207–271) | 434 (426–442) | ||||||
| PEAR1 | rs12041331 | GG (84.0) | 150 (143–158) | 249 (239–260) | 434 (431–436) | ||||
| GA (15.5) | 126 (111–143) | 203 (181–229) | 431 (424–437) | <0.0001 | <0.0001 | 0.04 | |||
| AA (0.5) | 46 (10–203) | 97 (11–859) | 407 (363–456) | ||||||
| PEAR1 | rs2768759 | CC (55.0) | 147 (138–157) | 246 (232–260) | 433 (430–436) | ||||
| CA (37.5) | 146 (136–157) | 239 (225–254) | 434 (430–438) | 0.39 | 0.30 | 0.84 | |||
| AA (7.5) | 136 (112–165) | 220 (183–265) | 431 (422–441) | ||||||
Values are geometric mean (95% confidence interval) or counts (%). Platelet aggregation data were logarithm transformed for analysis and back-transformed for presentation. All analyses are adjusted for the following baseline variables and cardiovascular risk factors: Age, sex, smoking, body mass index, previous myocardial infarction, diabetes, proton pump inhibitor use, and platelet count. P-values refer to differences in platelet aggregation across genotypes. Patients homozygous for the variant allele were pooled with heterozygotes for regression analysis. AA: arachidonic acid, AU: aggregation units, MEA: multiple electrode aggregometry (Multiplate Analyzer).