Figure 5.

Summary of in vivo measurements of PA1 and PA3 in a murine leg model. (A) Anatomical scan of mouse legs immediately after injection (top row) and after 4 days (bottom row). The PA injections are indicated by white arrows. PA1 produces positive contrast in white (left column), while PA3 produces negative contrast (right column). (B) T₁ maps of the same mouse at the same image positions as in A. Dark areas represent regions with very short T₁ times. (C) Averaged image T₁ times from regions of interest for all mice at all slices where PA was visible. Filler (unlabeled) PA was not visible (Figure S27). Filler PA T₁ was measured as a best approximation for PA position based on the injection location. Background was measured by averaging T₁ values of muscle tissue several millimeters from the PA injection.