TABLE 2.
Pairwise comparisons of predicted amino acid sequences of HMW adhesins from NTHi strains 12, 5, and 15
| Comparisona | % Similarity ± SD | % Identity ± SD | % Gaps ± SD |
|---|---|---|---|
| HMW1 vs. HMW1 matureb | 72 ± 4 | 62 ± 6 | 8 ± 1 |
| HMW2 vs. HMW2 mature | 69 ± 5 | 59 ± 5 | 11 ± 6 |
| HMW1 vs. HMW2 mature | 63 ± 7 | 52 ± 7 | 12 ± 5 |
| HMW1 vs. HMW1 binding domainc | 74 ± 4 | 63 ± 5 | 2 ± 1 |
| HMW2 vs. HMW2 binding domain | 69 ± 3 | 54 ± 3 | 2 ± 1 |
| HMW1 vs. HMW2 binding domain | 50 ± 2 | 35 ± 2 | 7 ± 1 |
a
Comparisons were done using the BLAST interface on the NCBI website.
b
Mature refers to the protein sequence after cleavage at the known and predicted cleavage sites (corresponding to the peptide bond between amino acids 441 and 442 of strain 12 HMW1 and HMW2).
c
Binding domain refers to the protein sequence corresponding to the binding domains of strain 12 HMW1 and HMW2 as defined by Dawid et al. (11).