Table 1. Functional and Radioligand Binding Data Obtained for NT, 1, 5a, 5b, and 6 at the NTS1 and NTS2 Receptors.

	FLIPR assay						bindinga
	NTS1			NTS2			NTS2
compd	EC50b	Emaxc	Ke	EC50	Emaxd	IC50	Ki
NT	0.04 ± 0.012	100 ± 3		NAe		18.5 ± 1.2	18.9 ± 3
1	0.01 ± 0.002	114 ± 7		NA		5.4 ± 0.6	33 ± 11
5a			4.7 ± 0.8	120 ± 20	100 ± 3		62 ± 35
5b			1.5 ± 0.6	20 ± 5	100 ± 5		6 ± 2
6	NA		NA	28 ± 4	16 ± 3		33 ± 5

^a[¹²⁵I]NT,

^bEC₅₀, K_e, IC₅₀, and K_i values are nM ± SEM.

^cE_max value is % NT.

^dE_max value is % 5b.

^eNot active.