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Direct inhibition of full-length factor XIa by variably sulfated SPGG variants as well as the synthesized decasulfated species. The inhibition of factor XIa by 4f (○), 4e (●), 4d (Δ), 4c (■), 4b (◇), 4a (▲), and 5 (□) was studied at pH 7.4 and 37 °C, as described in Experimental Procedures. Solid lines represent sigmoidal dose–response fits using eq 1 to the data to calculate the IC50, ΔY, and HS values.
