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Competitive direct inhibition of factor XIa by β-SPGG-8 (4f) (A), β-SPGG-2 (4c) (B), β-SPGG-1 (4b) (C), and β-SPGG-0.5 (4a) (D) in the presence of UFH. The inhibition was determined spectrophotometrically at pH 7.4 and 37 °C. Solid lines represent fits by the dose–response eq 1 to obtain the IC50,predicted, as described in Experimental Procedures. The concentrations of UFH selected for the study are provided.
