Table 4. Physicochemical Properties of Quinazolines.
a
(∗) For solubility ≤ 5 μM. (∗∗) For 5 μM < solubility ≤10 μM. (∗∗∗) For 10 μM < solubility ≤ 20 μM. (∗∗∗∗) For 20 μM < solubility ≤ 30 μM. (∗∗∗∗∗) For solubility ≥ 30 μM.
b
For the determination of the Pe values, the following internal controls were utilized: carbazepine pH 4.0 permeability Pe = 108 × 10–6 cm/s and pH 7.4 permeability Pe = 130 × 10–6 cm/s; ranitidine·HCl pH 4.0 permeability Pe = 5.2 × 10–6 cm/s and pH 7.4 permeability Pe = 2.2 × 10–6 cm/s; verapamil·HCl pH 4.0 permeability Pe = 20.6 × 10–6 cm/s and pH 7.4 permeability Pe = 1360 × 10–6 cm/s. n/d: not determined.