Table 2. PK Parameters of Sali after It Was Delivered As a Free Form or an Encapsulated Form in the NP3.
Sali | iTEP–Sali NP3 | |||
---|---|---|---|---|
mean | 95% CI | mean | 95% CI | |
initial vol of distribn (V0, μL/g) | 197.44 | 166.82–241.84 | 118.78 | 107.57–132.63 |
AUC (μM h) | 30.70 | 14.15–53.28 | 192.10 | 98.34–315.27 |
clearance (CL, μL/(h g)) | 216.87 | 124.96–470.52 | 34.66 | 21.12–67.70 |
elimination half-life (telimi, h) | 0.86 | 0.26–2.57 | 4.45 | 2.77–7.70 |
distribn half-life (tdistribn, h) | 0.43 | 0.29–1.19 | 0.63 | 0.40–1.08 |
R2 | 0.93 | 0.95 |