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. 2014 Aug 27;3(8):794–802. doi: 10.1016/j.molmet.2014.08.002

Figure 3.

Figure 3

Hyperinsulinemic-euglycemic clamp reveals increased insulin sensitivity in low fat diet-fed Bmi1+/− mice. Hyperinsulinemic-euglycemic clamp performed on 30 week-old males on LFD. Target glucose 120–140 mg/dL n = 5 mice per genotype. (A) Basal blood glucose levels, (B) basal hepatic glucose production, and (C) glucose infusion rate during clamp. Radioactive tracers were administered and quantitated to calculate (D) hepatic glucose suppression, (E) glucose disposal rate, and glucose uptake to muscle (F) and adipose tissue (G). *p < 0.005 compared to Bmi1+/+; **p < 0.001 compared to Bmi1+/+.