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Structure of rFVIIIFc. rFVIIIFc consists of a single B-domain deleted FVIII covalently fused to an Fc dimer with no intervening linker, resulting in a 220-kDa protein 15. Specific activity of rFVIIIFc ranges from approximately 8000 to 10 000 IU mg−1 (1760–2200 IU nmol−1), which is comparable to the specific activity for Advate®, reported at 1120–2800 IU nmol−1 24. rFVIIIFc, recombinant factor VIII Fc fusion protein.
