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Distribution of one-stage clotting assay results by dose level showing an approximate normal distribution for both rFVIIIFc and Advate®. (a) Advate® 0.8 IU mL−1, rFVIIIFc 0.87 IU mL−1; (b) Advate® 0.2 IU mL−1, rFVIIIFc 0.22 IU mL−1; (c) Advate® 0.05 IU mL−1, rFVIIIFc 0.054 IU mL−1. rFVIIIFc, recombinant factor VIII Fc fusion protein.
