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. 2014 Dec 5;369(1657):20130543. doi: 10.1098/rstb.2013.0543

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© 2014 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 4. — Epigenetic reprogramming of PGCs. Upon specification of PGCs at E6.5, a PGC-specific transcriptional network including BLIMP1, PRDM14 and AP2γ is activated. PRDM14 binds predominantly to enhancers, whereas BLIMP1 occupies mainly promoters. AP2γ shows bimodal enrichment and binds to both distal regulatory elements as well as promoters. These transcription factors synergistically repress somatic and proliferation genes and the expression of some epigenetic regulators. Further, they activate the expression of another set of epigenetic regulators as well as germ cell genes. These transcriptional changes are accompanied by epigenetic remodelling: H3K9me2 is progressively lost, H3K27me3 is enriched and DNA is globally demethylated. These epigenetic changes could potentially contribute to the remodelling of the enhancer landscape towards the capacity of totipotency. (Online version in colour.)