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Plaque reduction assays. (A to C) Blocking effect of an antibody to αvβ6 (10D5) on the infection of cells by CAV9 and the RGD-less mutant D4. −, no antibody; +, 1.0 μg of antibody. (A) CAV9 on GMK cells; (B) CAV9 on RD cells; (C) D4 on GMK cells. (D) Blocking of CAV9 infection in GMK cells by purified soluble αvβ6. Inhibition was measured by plaque reduction. Bars represent different amounts of αvβ6 incubated with CAV9 prior to addition to the cell monolayer.
