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. 2014 Nov 1;33(11):749–774. doi: 10.1089/dna.2014.2375

FIG. 9.

FIG. 9.

Mitochondrial exchange between adjacent cells and uptake of exogenous mitochondria by nuclei isolated from resistant U87 iCSCs. Donor cells depositing mitochondria in the nuclear perimeters of adjacent cells via a kind of varicosity (A–F). Mitochondrial injection into the perinuclear compartments of U87 GFP was documented by co-cultivation of U87 iCSCs labeled with red MitoTracker® and U87 GFP. Resistant cells transferred mitochondrial content to untreated cells (G–I): magnification of marked area in (H). (J–Q) Nuclei isolated from resistant U87 iCSCs previously labeled with red MitoTracker and exposed to exogenous mitochondria isolated from U87 iCSCs previously labeled with green MitoTracker. Incorporation of exogenous mitochondria led to the formation of a capsule inside which the nucleus continued its life cycle. GFP, green fluorescent protein. Color images available online at www.liebertpub.com/dna