TABLE 1.
Antibody inhibition of rotavirus-induced B-cell activation
| Protein specificity | Antibody | Virus antigen | Isotype | Neutralizing antibody | % Activated B cells |
|---|---|---|---|---|---|
| Anti-VP7 | KU-4 | KU | IgG3 | Yes | 4.7b |
| ST-2G7 | ST-3 | IgG2a | Yes | 5.2b | |
| 159 | RRV | IgG1 | Yes | 5.1b | |
| YO-1E2 | YO | IgG2b | Yes | 4.4b | |
| Anti-VP4 | 9F6 | SA11 CI3 | IgG1 | Yes | 21.2 |
| 954/23 | RRV | IgG1 | Yes | 9.6b | |
| 10G6a | SA11 CI3 | IgG1 | Yes | 9.9b | |
| Anti-VP6 | 255 | RRV | IgG | No | 23.0 |
| NAc | Control | NA | IgG1 | NA | 20.2 |
| Control | NA | IgG2a | NA | 22.6 | |
| Control | NA | IgG2b | NA | 15.6 | |
| Control | NA | IgG3 | NA | 21.8 |
a
Decapsidates virus (62).
b
P < 0.05 versus isotype control (Student's t test).
c
N/A, not applicable.