Table 2.
Summary of potential PRL effector molecules.
| PRL effector molecule |
Effect of PRL Overexpression |
Reference |
|---|---|---|
| p53 | Inhibition | (62,63) |
| Src | Activation | (54,67,68) |
| ERK1/2 | Activation | (54,67,68) |
| STAT3 | Activation | (54,67,68) |
| p130Cas | Activation | (54,67,68) |
| Csk | Inhibition | (54,67) |
| MMPs | Activation | (68) |
| FAK | Activation (PRL1) | (68) |
| Rho A and C | Activation | (10) |
| Rac | Inhibition | (10) |
| Integrin α | Inhibition | (71,72,73) |
| Integrin β | Enhance Src interaction |
(73,74, 75) |
| c-fos | Inhibition | (71) |
| Actin Cytoskeleton |
Uncoupling from adhesive proteins |
(69) |
| E-Cadherin | Inhibition | (70) |
| γ-catenin | Inhibition | (70) |
| Vinculin | Inhibition | (70) |
| Fibronectin | Protein level Up- regulation |
(70) |
| Snail | Protein Level Up- regulation |
(70) |
| PTEN | Inhibition | (70,76,77) |
| Akt | Activation | (70,76,77) |
| PDGFR | Activation | (75) |
| Eph | Activation | (75) |
| EGFR | Activation | (78) |
| PTP1B | Inhibition | (78) |
| KCNN4 | Activation | (79) |
| Phosphoinositides | Dephosphorylation | (80) |
| miR 21,17,19a | Induction | (81) |
| miR 495, 551a | Induction | (82) |
| STAT5 | Activation | (43) |
| Histone Deacetylase 4 |
Activation | (43) |
| Mcl-1 | Induction | (43) |