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Comparison of cell cycle profiles between UPCI:SCC066 (without distal 11q loss) and UPCI:SCC104 (with distal 11q loss) in response to IR. UPCI:SCC066 and 104 were either mock-treated or treated with 5 Gy IR and allowed to recover for 24 h. At the end of 24 h, flow cytometric analyses show loss of the G1 cell cycle checkpoint in UPCI:SCC104, with most cells accumulating in G2M, and accumulation of UPCI:SCC066 cells in both the G1 and G2M cell cycle phases.
