Table 5.
Blunted angiogenic potential in the kidney of fetuses exposed to maternal LP diet, as revealed by transcript expression of angiogenic factors
| Gene | Diet |
Sex |
P |
||||
|---|---|---|---|---|---|---|---|
| CP | LP | M | F | D | S | D × S | |
| Angiopoietin | 13.7 ± 0.79 | 11.5 ± 0.74 | 13.1 ± 0.74 | 11.9 ± 0.79 | 0.062 | NS | NS |
| Tie 2 | 1.52 ± 0.08 | 1.32 ± 0.07 | 1.40 ± 0.07 | 1.42 ± 0.08 | 0.065 | NS | NS |
| VEGFA | 13.7 ± 0.63 | 11.4 ± 0.59 | 12.8 ± 0.59 | 12.0 ± 0.63 | 0.014 | NS | NS |
| VEGFR1 | 16.7 ± 0.99 | 13.7 ± 0.92 | 14.4 ± 0.92 | 15.6 ± 0.99 | 0.036 | NS | NS |
Data are mean ± sem units × 10−2 for fetuses from ewes fed a CP diet (n=15) or an LP diet n=16) to d 65 gestation. Data were analyzed by the general linear mixed model for the fixed effects of diet (D), sex (S), or their interaction (D×S) using Genstat 14. NS, nonsignificant. Values of P < 0.05 were considered significant.