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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Mov Disord. 2014 Sep 4;29(13):1655–1665. doi: 10.1002/mds.26009

Figure 5. VU0255035 does not affect M2/M4 mAChR-mediated responses.

Figure 5

(A, B) Sample traces of striatal cholinergic interneurons recorded from both genotypes, showing a typical spontaneous, pacemaking firing activity. Bath-application of muscarine (10 μM, 90 s) causes a transient membrane hyperpolarization and cessation of firing activity in the recorded interneurons, recorded from both Tor1a+/+ and Tor1a+/Δgag mice. This inhibitory response, mediated by M2/M4 mAChRs, is not prevented by pretreatment with VU0255035 (100 nM) in both strains of mice.