(A, B) Sample traces of striatal cholinergic interneurons recorded from both genotypes, showing a typical spontaneous, pacemaking firing activity. Bath-application of muscarine (10 μM, 90 s) causes a transient membrane hyperpolarization and cessation of firing activity in the recorded interneurons, recorded from both Tor1a+/+ and Tor1a+/Δgag mice. This inhibitory response, mediated by M2/M4 mAChRs, is not prevented by pretreatment with VU0255035 (100 nM) in both strains of mice.