. Author manuscript; available in PMC: 2015 Sep 1.

Published in final edited form as: Pediatr Infect Dis J. 2014 Sep;33(9):946–952. doi: 10.1097/INF.0000000000000330

Table 3.

Analysis of Baseline HIV Log₁₀RNA Conditional on Genetic Markers, Adjusted by Age, Race, Study

Gene	SNP	Age X Genotype Interaction	Age Group	Level	Count	Adjusted Analysis			P-value cut off under FDR control at 0.1	Significant Controlling for FDR
Gene	SNP	Age X Genotype Interaction	Age Group	Level	Count	Slope (LCI, UCI)	P-value	Multivariate Wald Test P-value	P-value cut off under FDR control at 0.1	Significant Controlling for FDR
MBL2	MBL2_X/Y	0.6832	All	Y/Y	643	5.56(5.40,5.72)		0.041	0.017	-
				X/X	22	0.36(0.08,0.64)	0.012
				X/Y	203	0.04(−0.09,0.17)	0.520
HLA	HLA_C alleles	0.3946	All	Homozygote	100	5.75(5.53,5.97)		0.031	0.016	-
				Heterozygote	757	−0.19(−0.36,−0.02)	0.031
HLA	HLA_A alleles	0.0096	(0, 2]	Homozygote	41	5.97(5.69,6.24)		0.026	0.014	-
				Heterozygote	352	−0.27(−0.50,−0.03)	0.026
RANTES	RANTES_28-C/G	0.0186	(0, 2]	C/C	391	5.74(5.57,5.92)		0.020	0.013	-
				G/G+C/G	7	0.42(0.07,0.78)	0.020
HLA	HLA_Cw-6 alleles	0.0982	(2, 18]	Absence	391	4.60(4.40,4.79)		0.019	0.012	-
				Presence	72	0.22(0.03,0.40)	0.019
CX3CR1	CX3CR1_280-T/M	0.8325	All	C/C	763	5.52(5.36,5.69)		0.019	0.011	-
				T/T+C/T	105	0.19(0.03,0.35)	0.019
CCL3L1	CCL3L1_Copy Number	0.5775	All	[0, 2]	494	5.58(5.42,5.74)		0.016	0.010	-
				>=7	50	0.26(0.05,0.48)	0.015
				[3, 4]	235	−0.05(−0.18,0.09)	0.495
				[5, 6]	89	0.17(−0.02,0.36)	0.074
HLA	HLA_A-3 alleles	0.4840	All	Absence	718	5.53(5.36,5.69)		0.008	0.009	^*
				Presence	138	0.19(0.05,0.33)	0.008
CCR5	CCR5_wt/delta32	0.1969	All	wt/wt	815	5.63(5.46,5.80)		0.005	0.008	^*
				wt/D32	47	−0.35(−0.59,−0.11)	0.005
HLA	HLA_DRB1^*15 alleles	0.3394	All	Absence	610	5.52(5.35,5.68)		0.002	0.007	^**
				Presence	241	0.18(0.07,0.30)	0.002
HLA	HLA_DRB1^*10 alleles	0.4121	All	Absence	821	5.59(5.43,5.75)		0.002	0.006	^**
				Presence	30	−0.45(−0.73,−0.17)	0.002
HLA	HLA_B-27/57 alleles	0.6551	All	Absence	769	5.65(5.48,5.81)		<0.001	0.004	^**
				Presence	84	−0.36(−0.57,−0.16)	<0.001
HLA	HLA_B-14 alleles	0.6788	All	Absence	793	5.59(5.44,5.75)		<0.001	0.003	^**
				Presence	60	−0.39(−0.60,−0.18)	<0.001
HLA	HLA_Cw-8 alleles	0.7843	All	Absence	765	5.60(5.44,5.76)		<0.001	0.002	^**
				Presence	92	−0.46(−0.65,−0.26)	<0.001
HLA	HLA_B-57 alleles	0.9304	All	Absence	798	5.63(5.47,5.79)		<0.001	0.001	^**
				Presence	55	−0.54(−0.77,−0.31)	<0.001

Note: This table only includes the SNPs with multivariate Wald test nominal p-value <0.05. P-values are compared to the corresponding cut off values and p-values that are less than the cut off value are considered as significant under the FDR control at the pre-specified level.

-: Not significant at FDR=0.1

: Significant at FDR=0.1

^**

: Significant at FDR=0.1 and FDR=0.05