Table 1.
Distribution according to Serotype, Vaccine Relationship, and Penicillin Susceptibility of Streptococcus pneumoniae Isolates in Nasopharyngeal Cultures Obtained from Children with the Study Entry Episode of Acute Otitis Media during 2012-2013.
| Serotype or Serogroup* | Total Number of Isolates | Susceptibility of Isolate to Penicillin | |
|---|---|---|---|
| Susceptible† | Nonsusceptible | ||
| Number of isolates (%) | |||
| PCV7 | |||
| 19F | 1 | 1 (100) | --- |
| 23F | 1 | --- | 1 (100) |
| PCV7-related | |||
| 6, other than A and B | 2 | 1 (50) | 1 (50) |
| 9, other than V | 1 | 1 (100) | --- |
| 19 B | 1 | --- | 1 (100) |
| 23, other than F | 15 | 9 (60) | 6 (40) |
| PCV13 (other than PCV7) | |||
| 3 | 3 | 3 (100) | --- |
| 6A | 3 | 1 (33) | 2 (67) |
| 19A | 8 | 2 (25) | 6 (75) |
| Nonvaccine | |||
| 10A | 3 | 3 (100) | --- |
| 11A | 9 | 9 (100) | --- |
| 15‡ | 26 | 18 (69) | 8 (31) |
| 16F | 3 | 3 (100) | --- |
| 17F | 3 | 3 (100) | --- |
| 20 | 1 | 1 (100) | --- |
| 22 | 3 | 3 (100) | --- |
| 25A | 1 | 1 (100) | --- |
| 33 | 3 | 3 (100) | --- |
| 34 | 1 | 1 (100) | --- |
| 35‡ | 13 | 2 (15) | 11 (85) |
| 37 | 1 | 1 (100) | --- |
| 40 | 4 | 4 (100) | --- |
| 44 | 1 | --- | 1 (100) |
| group H (13, 28) | 1 | 1 (100) | --- |
| group E (21, 39) | 5 | 5 (100) | --- |
| TOTAL | 113 | 76 (67) | 37 (33) |
PCV7 denotes 7-valent pneumococcal conjugate vaccine. PCV13 denotes 13-valent pneumococcal conjugate vaccine.
Other serotypes (vaccine-included, vaccine-related, and nonvaccine) that were not found are not listed.
Penicillin-susceptible: Minimum inhibitory concentration (MIC) <0.1 μg/mL. Penicillin-nonsusceptible: MIC ≥0.1 μg/mL.
Includes multiple subtypes.
Numbers in parentheses refer to individual serotypes that constitute the respective Groups in their entirety. Isolates whose serotypes would have placed them into one of these Groups were characterized only by their Group identity; specific, individual serotype testing of these isolates was not performed.