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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Behav Pharmacol. 2014 Dec;25(8):758–765. doi: 10.1097/FBP.0000000000000094

Fig. 4.

Fig. 4

Effects of prior experimenter-administered MPD (2 mg/kg/day for 7 days) or saline on food- and METH-maintained (0.1 mg/kg/inf) responding. Each condition represents the mean ± SEM of 6-7 rats. Horizontal axis: Ticks indicate consecutive sessions. For clarity, only the last 3 sessions of the food and all sessions for drug components are shown. Rats were first pretreated with MPD, then underwent food training and surgery, and then were allowed to self-administer METH such that the same number of days occurred between MPD and METH (i.e. 14 days) as in Figs. 1 and 2. Vertical axis: mean (± SEM) food pellets or infusions earned. * p<0.05, values significantly different compared with saline/saline.