Responding on the operant discrimination task after changing to the 4 mg/kg MPH training dose. A,B) Responding on the injection paired lever (IPL), after either vehicle or 4mg/kg MPH injection, was similar for the two groups over 20 sessions of training. The dotted lines indicate criterion levels for the two measures. C) A comparison of FFR and IPL responding averaged over the last 3 days. No significant differences were found and most mice met discrimination criteria. D) Over the last 3 days of the training period, the two groups of mice had similar numbers of sessions of criterion level performance out of 30 possible. Data are mean + SEM except panel D, which are counts.