TABLE 2.

Sequence characteristics of antibody H-111 (GenBank accession numbers AY466500 and AY466501)^a

Characteristic	VL domain	VH domain
CDR length (amino acids)
CDR1	17	5
CDR2	7	17
CDR3	9	18
Germ line counterpart	B3, JK4	VH3-30, D3-22, JH5
V gene mutations (amino acids)
Replacement	11	21
Silent	11	13
Replacement/silent, CDRs	7/4	6/3
Replacement/silent, FRs	4/7	15/10
Junctional mutations (nucleotides)
Deletion	3	11
Insertion	0	15
Replacement	0	13

^aV gene amino acid mutation analysis does not include V_L or V_H domain CDR3. Junctional mutations refer to nucleotide mutations at the V_L domain V-J junction and at the V_H domain V-D and D-J junctions. Corresponding amino acid mutations are shown in Fig. 3. Mutations located at 3′ end of the J gene (well beyond the D-J junction) are not included.