Table 2.

Description of kidney histo-pathological diagnosis

Patient	Case 1	Case 2	Case 3	Case 4
Renal histology	MPGN type III	MPGN type III	Acute interstitial nephritis	MPGN type III
Light microscopy	Diffuse hypercellularity and thickening of glomerular basement membrane.	Subendothelial and subepithelial deposits with mesangial interposition associated with basement membrane spikes	Acute interstitial nephritis: edema associated with interstitial lymphoplasmocytic infiltration in addition to mild tubulointerstitial fibrosis.	Subendothelial and subepithelial deposits and mesangial interposition associated with basement membrane spikes.
		Free Leishmania in a capillary lumen	Tubules are invaded by lymphocytes and areas of necrosis are visualized.	Interstitial granuloma. Positive PCR for Leishmania infantum in urine and in renal biopsy
		Positive PCR for Leishmania infantum in the renal biopsy	Glomeruli are uninvolved. Free Leishmania in a capillary lumen
Immunofluorescence	Mesangial and endomembranous deposits of IgG, IgM, C3 and C1q	Fine granular deposition of IgG and C3 in the mesangium and along the peripheral capillary loops	Deposits of IgG and IgM with a mesangial pattern	Mesangial and endomembranous deposits of IgG and C3

MPGN: Membrano-proliferative glomeruolonephritis.

PCR: Polymerase Chain Reaction.