. 2014 Oct 16;2014:164391. doi: 10.1155/2014/164391

Table 2.

Cytotoxicity of ADR alone and in combination with VER or CH in K562 and K562/ADR cells in vitro.

Drug and concentration	IC₅₀ (μM)		Resistance times	Reversing times
Drug and concentration	K562	K562/ADR	Resistance times	Reversing times
ADR	0.45 ± 0.11	13.97 ± 0.30^*	31.04
ADR + CH (5 μM)	0.44 ± 0.12	1.62 ± 0.10^∗△	3.68	8.43
ADR + VER (5 μM)	0.46 ± 0.07	6.07 ± 0.18^∗△☆	13.19	2.35

Cells were exposed to various concentrations of ADR, with or without 5 μM CH, or VER for 48 h. ∗P < 0.05 compared with K562 treated with ADR, or ADR cotreated with CH or VER, ^△ P < 0.05 compared with K562/ADR treated with ADR, ^☆ P < 0.05 compared with K562/ADR treated with ADR plus CH.