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. Author manuscript; available in PMC: 2014 Nov 2.
Published in final edited form as: J Invest Dermatol. 2013 Jun 13;134(1):112–122. doi: 10.1038/jid.2013.266

Figure 5. The expression of β1 and β4 integrin is increased upon plakophilin 2 (PKP2) silencing.

Figure 5

(a) Staining of control (CTL) and PKP2-silenced normal human epidermal keratinocytes (NHEKs) demonstrates an increased amount of β1 and β4 integrin expressed by the PKP2 knockdown (KD) cells. Scale bar = 20 μm. (b) Whole-cell lysates of NHEKs demonstrate an elevated amount of both β1 and β4 integrin in steady-state PKP2 KD keratinocyte cultures compared with control cells. GAPDH, glyceraldehyde-3-phosphate dehydrogenase. (c) An α and β integrin ELISA demonstrates an increased amount of α and β integrin subunits expressed on the surface of SCC9 cells or NHEKs silenced for PKP2 (error bars ±SEM).