FIG. 2.

Infection of primary macrophages by patient LN and brain envelopes. (A) Infectivity titers for patient envelope-positive pseudotype viruses titrated on primary macrophages from different donors and on GHOST/CCR5 cells. Arrows indicate that infection is below the level of detection. Data are derived from duplicate infections on two donor macrophage batches. GHOST/CCR5 titers were derived from infectivity titrations carried out with the same batch of virus as in macrophage infections. (B) Macrophage-GHOST/CCR5 infectivity ratios indicate that patient envelopes NA20 B59, NA353 B27, NA420 B33, and NA176 B93 are highly macrophage tropic.