Table 5.
OR (95% CI) for metastasis of PTC by ATM gene polymorphisms according to different models of inheritance (adjusted by age and stage). P < 0.05 in bold.
| SNP, genotype | Male | Female | ||
|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | |
| rs664677 | ||||
| CCa | 1.00 | 1.00 | ||
| CT | 0.36 (0.04–3.41) | 0.54 | 4.32 (0.54–34.27) | 0.95 |
| TT | 0.63 (0.14–2.73) | 0.38 | 1.03 (0.40–2.66) | 0.17 |
| CT + TT versus CCb | 0.98 (0.35–2.75) | 0.97 | 0.74 (0.39–1.41) | 0.36 |
| TT versus CC + CTc | 0.75 (0.21–2.64) | 0.65 | 2.03 (0.86–4.82) | 0.11 |
| CT versus CC + TTd | 1.17 (0.44–3.12) | 0.75 | 0.54 (0.29–1.00) | 0.05 |
| Risk per T allelee | 0.91 (0.46–1.80) | 0.78 | 1.05 (0.66–1.67) | 0.84 |
| rs373759 | ||||
| GGa | 1.00 | 1.00 | ||
| GA | 1.94 (0.43–8.73) | 0.39 | 3.11 (0.98–9.88) | 0.06 |
| AA | 4.67 (0.34–65.00) | 0.25 | 3.01 (0.34–26.90) | 0.32 |
| GA + AA versus GGb | 1.81 (0.62–5.31) | 0.27 | 0.98 (0.52–1.84) | 0.96 |
| AA versus GG + GAc | 0.81 (0.15–4.24) | 0.80 | 1.66 (0.68–4.07) | 0.27 |
| GA versus GG + AAd | 1.83 (0.67–4.99) | 0.24 | 0.78 (0.42–1.44) | 0.43 |
| Risk per A allelee | 1.34 (0.60–2.98) | 0.48 | 1.13 (0.71–1.78) | 0.61 |
| rs4988099 | ||||
| AAa | 1.00f | 1.00 | ||
| AG | 0.73 (0.13–3.97) | 0.71 | 0.52 (0.17–1.57) | 0.24 |
| AG + GG versus AAb | — | — | 0.68 (0.24–1.94) | 0.46 |
| AG versus AA + GGc | — | — | 0.70 (0.25–2.00) | 0.50 |
| Risk per G allelee | — | — | 0.68 (0.24–1.88) | 0.44 |
| rs189037 | ||||
| GGa | 1.00 | 1.00 | ||
| GA | 1.58 (0.23–10.87) | 0.64 | 0.15 (0.04–0.56) | 0.01 |
| AA | 0.78 (0.05–13.51) | 0.87 | 0.08 (0.01–0.74) | 0.03 |
| GA + AA versus GGb | 1.87 (0.52–6.74) | 0.33 | 0.49 (0.25–0.98) | 0.04 |
| AA versus GG + GAc | 0.55 (0.14–2.09) | 0.37 | 1.29 (0.58–2.86) | 0.53 |
| GA versus GG + AAd | 2.18 (0.78–6.11) | 0.13 | 0.47 (0.25–0.89) | 0.02 |
| Risk per A allelee | 1.03 (0.47–2.25) | 0.95 | 0.79 (0.49–1.25) | 0.31 |
aCodominant model (wild homozygote serves as the reference).
bDominant model (combined heterozygote and homozygote for the minor allele versus wild homozygote).
cRecessive model (minor allele homozygote versus combined heterozygote and homozygote for the wild allele).
dOverdominant model (heterozygote versus combined homozygote for the wild and minor alleles).
eMultiplicative model (uses allele frequencies).
fJust gives OR (95% CI) and P-value for heterozygote versus wild homozygote (no GG genotype for males).