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. Author manuscript; available in PMC: 2014 Nov 2.
Published in final edited form as: Am J Transplant. 2013 Jul 8;13(9):2268–2279. doi: 10.1111/ajt.12342

Figure 1. Transient lymphopenia leads to rejection of cardiac allografts in CB conditioned recipients.

Figure 1

Figure 1

C57BL/6 mice received complete MHC-mismatched BALB/c heterotopic heart transplants with or without 500 μg of anti-CD40L mAb plus 500 μg of hCTLA4-Ig (CB conditioning) on the day of transplantation and every other day for 6 days to promote long-term allograft survival. One group of the CB conditioned recipients was (a) sub-lethally irradiated (6.5 Gy on day 60 post-transplant; and, (b) another group was treated on days 58, 59, and 60 post-transplant with CD4− and CD8− depleting antibodies. Allograft survival was monitored by palpation.