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AEG-1KO mice are resistant to age-associated spontaneous tumorigenesis. A. H & E staining of the indicated tissue sections of aged (16 m) AEG-1KO mouse demonstrating maintenance of normal histology and architecture. B. H & E staining of sections of liver, lung and heart of aged (16 m) WT mouse showing tumors. C. Immunohistochemical staining for AEG-1 in liver lymphoma of WT mouse. D. F4/80 staining for macrophages in liver sections of aged (16 m) WT and AEG-1KO mouse.
