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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Cancer Res. 2014 Sep 5;74(21):6184–6193. doi: 10.1158/0008-5472.CAN-14-1357

Fig. 2.

Fig. 2

AEG-1KO mouse is resistant to experimental hepatocarcinogenesis. A. Representative photograph of the livers of WT and AEG-1KO mice 32 weeks after DEN injection. B, top panel, H & E staining of liver sections; middle panel, AFP staining of the liver sections; bottom panel, AEG-1 staining of the liver sections. These samples were collected at 32 weeks after DEN injection. C. Serum levels of the indicated liver enzymes at the end of the study. AST: aspartate aminotransferase, ALT; alanine aminotransferase and Alk Phos: alkaline phosphatase. Data represent mean ± SEM. n = 12 for WT and n = 8 for AEG-1KO. *: p<0.01. D. Representative photograph of the livers of WT and AEG-1KO mice 28 weeks after initial DEN injection receiving PB in drinking water. E. H & E staining of liver sections at 28 weeks. F. top panel, H & E staining of the lungs showing lung metastasis in WT mouse; bottom panel, AFP staining of a metastatic lung tumor in WT mouse. G. F4/80 staining for macrophages in liver sections of WT and AEG-1KO mice treated with DEN alone (top panels) or DEN/PB (bottom panels).