Figure 3. SCCA1 promotes orthotopic breast tumor formation.
7.5 × 105 MCF10A cells expressing either GFP alone (n=5) or GFP plus SCCA1 (n=9) were implanted into the mammary fat pad of NOD-SCID mice. (A) Mice were imaged for tumor formation 60 days post implantation. (B) The formation of palpable tumors are summarized. Significance was judged based on Fischer’s exact test. **p < 0.01. (C) Tumors were sectioned and stained using H&E (top panels) or by IHC for SCCA (bottom panels).