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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Clin Cancer Res. 2014 May 6;20(21):5537–5546. doi: 10.1158/1078-0432.CCR-13-3003

Fig. 2.

Fig. 2

Gene expression profiling of brain and extracranial metastases. (A) Hierarchical clustering of log2 expression values of 8050 probes in 27 brain metastases (BM, orange) and 25 extracranial metastases (EM, black). Probes that showed less than 1.5-fold change from the median in more than 80% of the samples were excluded. Matched tumors are connected with arcs. (B) Differences in expression of 13 genes between paired BM and EM. Fold changes of gene expression from EM to BM were converted into log2 ratios. Log2 ratios in six pairs of samples were plotted as dots for each gene, means and standard deviations were plotted as horizontal bars. (C) Expression of SGK3, SGSM2 and ELOVL2 in matched BM and EM of six patients. Each column represents the expression value of one sample. (D) Expression of SGK3, SGSM2 and ELOVL2 in unmatched BM (N=21) and EM (N=19). Each dot represents the expression value of one sample.