Figure 3.

The bar graphs show the mean and standard error for skin temperature in the index finger (A) the thenar eminence (B) and the volar forearm (C) for the healthy volunteers (Vols, open bars) and the patients at the pretreatment baseline (Base, black bars) and at each cumulative dose treatment category (gray bars, “Low” is up to 370.6 mg; medium (Med) is up to 795.6 mg; “High” is up to 2328.2 mg and “Follow” is 6 months after tretament). The horizontal lines indicate the comparions made and * = p<0.05.