Figure 5.

The bar graphs show the mean and standard error for cool detection threshold (A) and cold pain threhsold (B) for the healthy volunteers (open bars) and the patients at the pretreatment baseline (black bars) and at each cumulative dose treatment category (“Low” is up to 370.6 mg, gray bars; medium (Med) is up to 795.6 mg, black cross hatch; “High” is up to 2328.2 mg, gray diagonal narrow cross hatch; and “Follow” is 6 months after tretament, black diagonal wide cross hatch). The horizontal lines indicate the comparions made and * = p<0.05; ** = p<0.01; *** = p<0.001.