Table 2.
Demographics, Tumor Characteristics, and Clinical Outcomes by PTEN Status.
| Measure | PTEN Absent (N=31) | PTEN Not Absent (N=93) | p-value |
|---|---|---|---|
| Gender, n (%) | |||
| Male | 22 (71) | 63 (68) | 0.826a |
| Female | 9 (29) | 30 (32) | |
| Age at Stage III diagnosis (years), median (range) | 48 (26.3, 82.4) | 58.1 (24.9, 85.4) | 0.073b |
| Clinical/Pathological Type, n (%) | |||
| Acral | 4 (13) | 12 (13) | 0.878a |
| Cutaneous | 20 (65) | 65 (70) | |
| Mucosal | 1 (3) | 3 (3) | |
| Unknown Primary | 6 (19) | 13 (14) | |
| Breslow thickness (mm), median (range) | 3.2 (0.4, 25.0) | 3.2 (0.3, 33.0) | 0.462b |
| Ulceration, n (%) | |||
| No | 6 (30) | 10 (15) | 0.188a |
| Yes | 14 (70) | 56 (85) | |
| Missing | 11 | 27 | |
| Time to any recurrence (years), median (95% CI) | 0.7 (0.5, 1.1) | 0.7 (0.5, 0.9) | 0.913c |
| Time to any distant recurrence (years), median (95% CI) | 0.9 (0.6, 1.4) | 1.2 (0.7, 1.7) | 0.352c |
| Overall survival (years), median (95% CI) | 1.9 (1.5, 2.1) | 3.1 (2.0, 4.1) | 0.031c |
| Time to CNS metastasis (years), median (95% CI) | 1.8 (1.2, 2.5) | 4.9 (2.4, NE) | 0.030c |
| Time to lung metastasis (years), median (95% CI) | 2.1 (1.1, NE) | 3.3 (1.9, 6.1) | 0.920c |
| Time to liver metastasis (years), median (95% CI) | NE (1.4, NE) | 6.3 (3.0, NE) | 0.522c |
| Time to bone metastasis (years), median (95% CI) | NE (1.4, NE) | NE (6.3, NE) | 0.102c |
a
Fisher’s exact test.
b
Wilcoxon rank sum test.
c
Log-rank test.
Abbreviations: CI = confidence interval; NE = not estimated.