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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Cancer Res. 2014 Sep 12;74(21):6271–6279. doi: 10.1158/0008-5472.CAN-14-1656

Figure 3.

Figure 3

Uptake of EGF-750 Probe detected via Immunocytochemistry. To demonstrate retention of biopotency of EGF in a validated fluorescent probe complex, Texas Red-EGF was incubated with three pancreatic cancer cell lines and analyzed at various time points (0, 10, and 30 min). S2VP10 and MiaPaCa-2 cell lines show internalization of labeled EGFR-Texas Red-EGF complex (red), while MCF7 (low EGFR-expressing) cells exhibit significantly reduced receptor-ligand internalization even with similar levels of endocytosis activity, apparent via labeled EEA1 antibody (green).