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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Biochim Biophys Acta. 2014 May 2;1848(0):299–306. doi: 10.1016/j.bbamem.2014.04.021

Figure 4. Amino acid sequence alignment of FXYD homology domains.

Figure 4

(A) FXYD family proteins. (B-D) Proteins obtained by BLAST search of the NCBI database against the DVDPYYD polypeptide sequence. (B) Membrane proteins containing entire FXYD protein sequences, including conserved FXYD and transmembrane (TM) motifs. The Down syndrome cell adhesion molecule-like protein (DSCAM, ELK11872) contains two FXYD protein sequences from residues 24–67 and 91–137. (C) Other membrane proteins with a FXYD motif preceding a TM sequence. (D) Soluble protein sequences with a conserved FXYD motif. Alignments were generated with ClustalW [57] in Jalview [58], and rendered with ClustalW coloring. Transmembrane sequences were identified with TMHMM [56]. FASTA-formatted alignments are provided in Supporting materials.