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Model of HTLV-1 LTR activation by Tax. Tax relieves transcriptional repression. On the nonactivated LTR, HDAC1 is associated with the template, probably through its interaction with cellular proteins bound to the LTR. In the presence of Tax, HDAC1 is released from the LTR through its interaction with Tax. Tax increases CREB association on the LTR, and the Tax/CREB/DNA complex recruits p300/CBP and RNAP II to activate transcription.
