. Author manuscript; available in PMC: 2015 Apr 7.

Published in final edited form as: Dement Geriatr Cogn Disord. 2014 Apr 7;38(1-2):89–146. doi: 10.1159/000357839

Table 3.

The Clinician’s Interview Based Impression of Change with Caregiver Input (CIBIC-Plus) and the NYU-CIBIC-Plus Assessment^*

A Wording used in the memantine pivotal trial for the NYU-CIBIC-Plus final assessment [17]

Is the subject?	Score
Markedly improved	1
Moderately improved	2
Minimally improved	3
Unchanged	4
Minimally worse	5
Moderately worse	6
Markedly worse	7

B Procedures for the assessment of the NYU-CIBIC-Plus
Must be obtained by a clinician independent of other study data The CIBIC rater must be blind to other study data Uses semi-structured ascertainment methodologies to arrive at final severity assignments Contains both direct patient assessment and informant assessment procedures Systematically surveys cognition, function, and behavior

C The NYU-CIBIC-Plus is the most detailed and comprehensive of the CIBIC-Plus procedures. These NYU-CIBIC-Plus procedures include the following:
All CIBIC-Plus procedures described above in A and B. Part 1: A subject (patient) assessment using validated semi-structured interviews assessing cognition and behavior. The subject-based assessment includes: A cognitive component. This systematically surveys the following areas: Concentration Recent memory Remote memory Orientation Based upon previously validated procedures described in Reisberg and Ferris [53]. A behavioral component. This systematically surveys the following areas: Paranoid and Delusional Ideation Hallucinations Activity Disturbances Agitation Affective Disturbances Anxiety and Phobias Based upon previously validated procedures described in Auer et al. [12]. Part 2: An informant (caregiver) assessment using a validated semi-structured interview assessing functioning and behavior. The informant-based assessment includes: A functional component. This systematically assesses the level and occurrence of the functional disability using validated procedures described in Sclan and Reisberg [20]. A behavioral component. This systematically assesses behavioral disturbances in the following areas: Paranoid and Delusional Ideation Hallucinations Activity Disturbances Aggressiveness Diurnal Rhythm Disturbances Affective Disturbances Anxieties and Phobias Based upon procedures validated in Reisberg et al. [1] and Sclan et al. [83]. Procedures for combining this comprehensive information towards ascertainment of a CIBIC-Plus severity rating [13].

C The NYU-CIBIC-Plus is the most detailed and comprehensive of the CIBIC-Plus procedures. These NYU-CIBIC-Plus
procedures include the following:

All CIBIC-Plus procedures described above in A and B.
Part 1: A subject (patient) assessment using validated semi-structured interviews assessing cognition and behavior.
The subject-based assessment includes:
1. A cognitive component. This systematically surveys the following areas:
  1. Concentration
  2. Recent memory
  3. Remote memory
  4. Orientation
  Based upon previously validated procedures described in Reisberg and Ferris [53].
2. A behavioral component. This systematically surveys the following areas:
  1. Paranoid and Delusional Ideation
  2. Hallucinations
  3. Activity Disturbances
  4. Agitation
  5. Affective Disturbances
  6. Anxiety and Phobias
  Based upon previously validated procedures described in Auer et al. [12].
Part 2: An informant (caregiver) assessment using a validated semi-structured interview assessing functioning and behavior.
The informant-based assessment includes:
1. A functional component. This systematically assesses the level and occurrence of the functional disability using validated procedures described in Sclan and Reisberg [20].
2. A behavioral component. This systematically assesses behavioral disturbances in the following areas:
  1. Paranoid and Delusional Ideation
  2. Hallucinations
  3. Activity Disturbances
  4. Aggressiveness
  5. Diurnal Rhythm Disturbances
  6. Affective Disturbances
  7. Anxieties and Phobias
  Based upon procedures validated in Reisberg et al. [1] and Sclan et al. [83].
Procedures for combining this comprehensive information towards ascertainment of a CIBIC-Plus severity rating [13].