Fig. 2.

Association between procoagulant microvesicle number, procoagulant derived thrombin generation and mortality. (a). Numbers of procoagulant MV of platelet origin (CD41+/AnnV+) in the plasma of samples at admission to hospital from trauma survivors and non-survivors. There is a significantly greater number of platelet derived procoagulant MV in plasma from survivors (n=41, median=202.1 per µL; IQR: 93.4–561.7) when compared to participants who died (n=9, median=40.2 per µL; IQR: 38.6–133.5) (p=0.015). Survival correlated positively with CD41/AnnV+ MV numbers (p=0.01, r=0.35). (b). Endogenous thrombin potential values in admission samples from trauma survivors and non-survivors. Box plots of median ETP values (PRP reagent) comparing survivors with non-survivors. The PRP ETP result at admission was significantly lower in patients who died (median=1524.5 per µL; IQR: 1155.5–1551.5) relative to those who survived to day 28 (median=1732.3 per µL; IQR: 1466–1973.9) (p=0.025).