Table III.
Trauma time 0 h | Trauma time 72 h | Controls | ||||
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Sample | Median | IQR | Median | IQR | Median | IQR |
Lagtime (min) | 5.9* | 4.8–6.3 | 9.0 | 8.3–10.0 | 6.7 | 6.1–7.3 |
ttPeak (min) | 10.8* | 9.1–12.5 | 16.6 * | 14.9–17.7 | 14.9 | 13.6–15.6 |
Peak thrombin (nM) | 160 * | 124–199 | 68 | 50–85 | 58 | 43–67 |
ETP (nM) | 1,671 * | 1,421–1,968 | 1,335 * | 1,199–1,554 | 918 | 790–1,205 |
This table depicts data for thrombin generation using PRP reagent. Data for the trauma cohort (at time 0 and time 72 h) were compared with a control group – all significant results (p<0.05) are marked with an
All 4 CAT parameters at time 0 h were significant relative to the control group (p≤0.001 for all parameters, except lagtime; p=0.003), indicating thrombin generation was greater and occurred more rapidly in the trauma group. Comparison between the 2 time points showed significant differences (ETP: p=0.02; lagtime, peak and ttPeak: p≤0.001) with time 0 h results being overall faster and having higher thrombin production.