TABLE 1.
Comparison of Yxxφ and diacidic motifs found in the cytoplasmic domain of SARS-CoV U274 protein to those found in other known transmembrane proteinsa
| Protein | NCBI identifier (no.) | Yxxφ and (D/E)×(E/D) motif |
|---|---|---|
| U274 | Virus (37361915) | TM-38aa-YNSVTDTIVVTEGD-101aa |
| VSV-G | Virus (138311) | TM-18aa-YTDIEMNRLGK |
| VZV-GPI | Virus (138246) | TM-20aa-YAGLPVDDFEDSESTDTEEEF |
| TfR | Human (136378) | 19aa-YTRFSLARQVDGDNSHV-26aa-TM |
| LDLR (proximal) | Human (126073) | TM-17aa-YQKTTEDEVHICH-20aa |
| LDLR (distal) | Human (126073) | TM-34aa-YSYPSRQMVSLEDDVA |
| CI-M6PR | Mouse (1709091) | TM-26aa-YSKVSKEEETDENE-127aa |
| CD-M6PR | Mouse (127294) | TM-34aa-YRGVGDDGLGEESEERDDHLLPM |
| ASGPR (H1 subunit) | Human (126132) | MTKEYQDLQHLDNEES-24aa |
| CD3δ | Mouse (115986) | TM-21aa-YQPLRDREDTQ-14aa |
| CD3γ | Mouse (115994) | TM-21aa-YQPLKDREYDQ-12aa |
| LAP | Human (130727) | TM-8aa-YRHVADGEDHA |
a
The Yxxφ motif is underlined, and the acidic residues conforming to the diacidic [(D/E)×(E/D)] signal are in boldface. Sequences were obtained from National Center for Biotechnology Information (NCBI). Abbreviations: VSV-G, vesicular stomatitis virus glycoprotein; VZV-GPI, varicella-zoster virus glycoprotein; LDLR, low-density lipoprotein receptor; CI-M6PR, cation-independent mannose 6-phosphate receptor; CD-M6PR, cation-dependent mannose 6-phosphate receptor; ASGPR, asialoglycoprotein receptor. aa, amino acid(s).