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. 2014 Oct 6;3(10):e120. doi: 10.1038/oncsis.2014.34

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Copyright © 2014 Macmillan Publishers Limited

Oncogenesis is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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LPAR6 mediates LSD1-controlled migration. (a) Levels of PXN and PXN Y118ph. (b) Migration assay of PC-3M-luc cells treated with LPA or Ethanol (EtOH). (d) mRNA levels of LPAR6 were analysed by qRT-PCR. (e) Migration assay of PC-3M-luc cells treated with LPA or EtOH and transfected with siRNA against LPAR6 or an unrelated control siRNA. (g) Migration assay of PC-3M-luc cells treated with siRNA either against LSD1, LPAR6 or both. (h) mRNA levels of LSD1 and LPAR6 were analysed by qRT-PCR. (i) Migration assay of PC-3M-luc cells overexpressing LPAR6. (b, e, g, i) Cell indices and relative velocities are shown. (a, c, f, k) Levels of LSD1, PXN, and PXN Y118ph were analysed by western blots decorated with the indicated antibodies. β-Actin was used as loading control. n⩾3. Error bars represent±s.d. or +s.d. *P⩽0.05, **P⩽0.01, ***P⩽0.001.

LPAR6 mediates LSD1-controlled migration. (a) Levels of PXN and PXN Y118ph. (b) Migration assay of PC-3M-luc cells treated with LPA or Ethanol (EtOH). (d) mRNA levels of LPAR6 were analysed by qRT-PCR. (e) Migration assay of PC-3M-luc cells treated with LPA or EtOH and transfected with siRNA against LPAR6 or an unrelated control siRNA. (g) Migration assay of PC-3M-luc cells treated with siRNA either against LSD1, LPAR6 or both. (h) mRNA levels of LSD1 and LPAR6 were analysed by qRT-PCR. (i) Migration assay of PC-3M-luc cells overexpressing LPAR6. (b, e, g, i) Cell indices and relative velocities are shown. (a, c, f, k) Levels of LSD1, PXN, and PXN Y118ph were analysed by western blots decorated with the indicated antibodies. β-Actin was used as loading control. n⩾3. Error bars represent±s.d. or +s.d. *P⩽0.05, **P⩽0.01, ***P⩽0.001.