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. 2014 Nov;24(11):1830–1841. doi: 10.1101/gr.176792.114

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© 2014 Keane et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 5. — Duplicates tolerate more nonsynonymous SNPs (NSNPs) than singletons. (A) A larger proportion of duplicates accumulate NSNPs (black portions) than singletons. (B) Most of the tolerance to NSNPs is found in duplicates originated by small-scale duplications (SSD), while those originated by whole-genome duplication (WGD) are not more enriched for NSNPs than are singletons when taking each duplicate as an independent gene.