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. 2014 Nov;24(11):1830–1841. doi: 10.1101/gr.176792.114

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© 2014 Keane et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 6. — Duplicate gene copies that interact genetically are more enriched for nonsynonymous SNPs (NSNPs) than genetically interacting singletons. We built a distribution of singleton interacting pairs randomly sampled that was not biased by highly interacting singletons. (A) Duplicate interacting pairs are more enriched for NSNPs than expected (black arrow; probability of the number of observed duplicates with NSNPs is indicated above the arrow). (B) Pairs of whole-genome duplicates (WGDs) with interacting gene copies are not more enriched than expected. (C) Small-scale duplicates (SSDs) with interacting gene copies are more enriched for NSNPs than expected.