Fig. 4.

Metabolic phenotyping of Gα_i2^−/− animals. A: body weight gain of wt and Gα_i2^−/− mice. Body weight of Gα_i2^−/− mice is significantly reduced. B: blood glucose levels determined in wt and Gα_i2^−/− mice over time, which are comparable between the 2 genotypes (n = 16 animals per genotype). C: blood glucose levels in 8- to 10-wk-old wt (■) and Gα_i2^−/− () mice following ip application of glucose after overnight fasting are equal (n = 8 animals per group). D: plasma insulin levels during ip glucose tolerance testing in wt and Gα_i2^−/− animals (n = 8 animals per group). Plasma insulin levels are significantly reduced at 15, 30, and 60 min. E: insulin tolerance testing in 4-h-fasted wt and Gα_i2^−/− mice (n = 6 per genotype). *P < 0.05.