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Insulin secretion experiments in ctrl and Gαi2βcko islets. A: glucose-induced insulin secretion measured at 3 and 16 mM glucose and 30 mM KCl (3 mM glucose: ctrl n = 60; Gαi2βcko n = 59; n, number of incubations). Inhibitory effect of clonidine (B) and SST (C) on glucose-induced insulin secretion (1 μM clonidine: ctrl n = 15; Gαi2βcko n = 14) was not affected by deletion of Gαi2 in β-cells. All conditions were performed in islet preparations derived from ≥3 animals per genotype.
