Fig. 8.
Effect of different stimuli on insulin secretion experiments in ctrl and Gαi2βcko islets. Stimulatory effect of palmitic acid (A), and l-leucine (B) was not affected by deletion of Gαi2 in β-cells. Potentiating effect of l-arginine (C) and l-ornithine (D) on insulin secretion was significantly reduced in Gαi2βcko (n, number of incubations). All conditions were performed in islet preparations derived from ≥3 animals per genotype. E: plasma insulin levels before and 1 min after ip injection of l-ornithine.